Selected article for: "human protein and large number"
Author: Qiang Huang; Andreas Herrmann
Title: Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV)
  • Document date: 2020_2_3
    • ID: eecyduzq_29
    Snippet: We have performed large-scale protein-protein docking to evaluate the binding affinities of SARS-CoV and 2019-nCoV S-RBDs to the human receptor ACE2, in order to quantitatively assess the human receptor-binding capability of 2019-nCoV. Using the well-investigated SARS-CoV as the reference, our results showed that 2019-nCoV reaches about 73% of the ACE2 receptor-binding strength of SARS-CoV. This supports that the 2019-nCoV S-protein encoded by it.....
    Document: We have performed large-scale protein-protein docking to evaluate the binding affinities of SARS-CoV and 2019-nCoV S-RBDs to the human receptor ACE2, in order to quantitatively assess the human receptor-binding capability of 2019-nCoV. Using the well-investigated SARS-CoV as the reference, our results showed that 2019-nCoV reaches about 73% of the ACE2 receptor-binding strength of SARS-CoV. This supports that the 2019-nCoV S-protein encoded by its genome has processed human receptor-binding ability close to that of SARS-CoV, and thus this newly emerged virus is likely able to bind to ACE2 and then to drive human-to-human transmission. However, the docking sampling for a large number of thermodynamically probable conformations did not find any binding conformation with an energy score lower than that of the lowest-energy conformation of SARS-CoV derived from experimentally determined structure, offering molecular evidence that the receptor-binding ability of 2019-nCoV is less than that of SARS-CoV.

    Search related documents:
    Co phrase search for related documents
    • bind affinity and human human: 1, 2, 3
    • bind affinity and human receptor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • bind affinity and human receptor bind: 1
    • bind affinity and investigate SARS CoV: 1
    • bind affinity and large number: 1, 2, 3
    • bind affinity and large scale: 1
    • bind conformation and human receptor: 1, 2, 3, 4
    • bind conformation and investigate SARS CoV: 1
    • energy score and human human: 1
    • energy score and human human transmission: 1
    • energy score and human receptor: 1, 2, 3
    • energy score and investigate SARS CoV: 1
    • energy score and large number: 1
    • energy score and low energy: 1, 2, 3, 4, 5, 6
    • experimentally determine and large number: 1
    • genome encode and human human: 1, 2
    • genome encode and investigate SARS CoV: 1
    • genome encode and large number: 1
    • genome encode and large scale: 1