Author: Said Mougari; Nisrine Chelkha; Dehia Sahmi-Bounsiar; Fabrizio Di Pinto; Philippe Colson; Jonatas Abrahao; Bernard La Scola
Title: First evidence of host range expansion in virophages and its potential impact on giant viruses and host cells Document date: 2019_9_24
ID: itxrhjns_1
Snippet: Host range is defined as the number and nature of hosts in which a virus can multiply 1 . This parameter is predicted to play a determinant role in virus pathogenicity, maintenance in nature and epidemiology 2 . Some viruses have evolved the capacity to expand their host range by biologically adapting to novel hosts. This phenomenon is known as host range expansion and requires the selection of specific mutations that enable a given viral species.....
Document: Host range is defined as the number and nature of hosts in which a virus can multiply 1 . This parameter is predicted to play a determinant role in virus pathogenicity, maintenance in nature and epidemiology 2 . Some viruses have evolved the capacity to expand their host range by biologically adapting to novel hosts. This phenomenon is known as host range expansion and requires the selection of specific mutations that enable a given viral species to replicate in a novel host 3 . In bacteriophages, such host range mutations target mostly the genes encoding the viral tail and baseplate involved in attachment to a receptor at the host cell surface 4, 5 .
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