Selected article for: "dose fractionation and vaccine action"
Author: Joseph T. Wu; Corey M. Peak; Gabriel M. Leung; Marc Lipsitch
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study
  • Document date: 2016_5_14
    • ID: ejqq2wmi_77
    Snippet: We consider the all-or-nothing YF vaccine action mechanism more likely than the leaky 638 vaccine action model for the following reasons: based on the limited evidence on 639 immunogenicity of fractional doses to date, we consider it unlikely that reducing the dose 640 five-fold or perhaps further from current preparations would result in dramatically lower 641 efficacy of the leaky type. Visual inspection of the data from a dose fractionation tr.....
    Document: We consider the all-or-nothing YF vaccine action mechanism more likely than the leaky 638 vaccine action model for the following reasons: based on the limited evidence on 639 immunogenicity of fractional doses to date, we consider it unlikely that reducing the dose 640 five-fold or perhaps further from current preparations would result in dramatically lower 641 efficacy of the leaky type. Visual inspection of the data from a dose fractionation trial of the 642 17DD vaccine in Brazil shows that for doses down to 47x below the standard dose, the 643 distribution of serologic responses was indistinguishable from those for the standard dose, 644

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