Author: Stuart Weston; Rob Haupt; James Logue; Krystal Matthews; Matthew B. Frieman
Title: FDA approved drugs with broad anti-coronaviral activity inhibit SARS-CoV-2 in vitro Document date: 2020_3_27
ID: jbc74lcu_11
Snippet: Nonlinear regression analysis was performed on the normalized %inhibit and %TOX data and IC50s and CC50s were calculated from fitted curves (log [agonist] versus response -variable slope [four parameters]) (GraphPad Software, LaJolla, CA), as described previously (7). Drug dilution points in a given run were excluded from IC50 analysis if the average cytotoxicity was . CC-BY-NC-ND 4.0 International license author/funder. It is made available unde.....
Document: Nonlinear regression analysis was performed on the normalized %inhibit and %TOX data and IC50s and CC50s were calculated from fitted curves (log [agonist] versus response -variable slope [four parameters]) (GraphPad Software, LaJolla, CA), as described previously (7). Drug dilution points in a given run were excluded from IC50 analysis if the average cytotoxicity was . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.008482 doi: bioRxiv preprint greater than 30% (arbitrary cutoff) across the 3 cytotoxicity replicates for that screen. IC50 or CC50 values extrapolated outside the drug dilution range tested were reported as greater than 50µM or less than 0.39µM. Selectivity indexes (SI) were also calculated by dividing the CC50 by the IC50.
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