Difficulty of downscaling the precautions for coronavirus disease-19 based on negative throat polymerase chain results in the early phase of infection()

Suzuki, Tetsuya; Kutsuna, Satoshi; Nakamura, Keiji; Ide, Satoshi; Moriyama, Yuki; Saito, Sho; Morioka, Shinichiro; Ishikane, Masahiro; Kinoshita, Noriko; Hayakawa, Kayoko; Ohmagari, Norio

We here report a case of coronavirus disease-19 (COVID-19) in Japan in which the initial throat swab polymerase chain reaction result was negative The possibility of false-negative results in the early phase of disease suggest reconsideration of the feasibility of a community or national infection control framework to prevent transmission. We recommend establishing an alternative feasible system, such as self-isolation by contact history in non-endemic community and by symptoms in endemic community, not relying on the PCR examination, to minimize this ongoing COVID-19 outbreak. Further rapid accumulation of knowledge including incubation period, clinical course and types of transmission is warranted to control this outbreak.