Author: Abbas, Mohammad; Verma, Sushma; Verma, Shrikant; Siddiqui, Sahabjada; Khan, Faizan H.; Raza, Syed T.; Siddiqi, Zeba; Eba, Ale; Mahdi, Farzana
Title: Association of GSTM1 and GSTT1 gene polymorphisms with COVIDâ€19 susceptibility and its outcome Cord-id: y26z05eu Document date: 2021_6_12
ID: y26z05eu
Snippet: Coronavirus disease 2019 (COVIDâ€19) caused by severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) infection has become a global health issue and develops into a broad range of illnesses from asymptomatic to fatal respiratory diseases. SARSâ€CoVâ€2 infection is associated with oxidative stress that triggers cytokine production, inflammation, and other pathophysiological processes. Glutathioneâ€Sâ€transferase (GST) is an important enzyme that catalyzes the conjugation of glutath
Document: Coronavirus disease 2019 (COVIDâ€19) caused by severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) infection has become a global health issue and develops into a broad range of illnesses from asymptomatic to fatal respiratory diseases. SARSâ€CoVâ€2 infection is associated with oxidative stress that triggers cytokine production, inflammation, and other pathophysiological processes. Glutathioneâ€Sâ€transferase (GST) is an important enzyme that catalyzes the conjugation of glutathione (GSH) with electrophiles to protect the cell from oxidative damage and participates in the antioxidant defense mechanism in the lungs. Thus, in this study, we investigated the role of GSTM1 and GSTT1 gene polymorphism with COVIDâ€19 susceptibility, as well as its outcome. The study included 269 RTâ€PCR confirmed COVIDâ€19 patients with mild (n = 149) and severe (n = 120) conditions. All subjects were genotyped for GSTM1 and GSTT1 by multiplex polymerase chain reaction (mPCR) followed by statistical analysis. The frequency of GSTM1(−/−), GSTT1(−/−) and GSTM1(−/−)/GSTT1(−/−) was higher in severe COVIDâ€19 patients as compared to mild patients but we did not observe a significant association. In the Cox hazard model, death was significantly 2.28â€fold higher in patients with the GSTT1(−/−) genotype (p = 0.047). In combination, patients having GSTM1(+/+) and GSTT1(−/−) genotypes showed a poor survival rate (p = 0.02). Our results suggested that COVIDâ€19 patients with the GSTT1(−/−) genotype showed higher mortality.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date