Author: James T. Van Leuven; Martina M. Ederer; Katelyn Burleigh; LuAnn Scott; Randall A. Hughes; Vlad Codrea; Andrew D. Ellington; Holly Wichman; Craig Miller
Title: FX174 Attenuation by Whole Genome Codon Deoptimization Document date: 2020_2_11
ID: mpb4fy16_30
Snippet: Assuming a selective explanation, it could be that codon usage controls the stoichiometric ratio between viral genes (91) , temporally regulates gene expression (42, 73, 92) , facilitates co-translational folding (33) , dampens protein expression to avoid host immune responses (64, 93) , or is limited by other compositional features. Comparative genomics between ΦX174, G4, α3, and ΦMH2K suggest that the codon usage biases are a conserved featu.....
Document: Assuming a selective explanation, it could be that codon usage controls the stoichiometric ratio between viral genes (91) , temporally regulates gene expression (42, 73, 92) , facilitates co-translational folding (33) , dampens protein expression to avoid host immune responses (64, 93) , or is limited by other compositional features. Comparative genomics between ΦX174, G4, α3, and ΦMH2K suggest that the codon usage biases are a conserved feature of these microviruses (94) . Our data cannot point towards any one of these explanations, although we note that the high-copy number proteins of ΦX174 tend to have higher CAI values and are more easily deoptimized.
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