Selected article for: "ion transport and short circuit"

Author: Ali Gibran; Runzhen Zhao; Mo Zhang; Krishan G. Jain; Jianjun Chang; Satoshi Komatsu; Xiaohui Fang; Beiyun Zhou; Jiurong Liang; Dianhua Jiang; Mistuo Ikebe; Michael A Matthay; Hong-Long Ji
Title: Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair
  • Document date: 2020_3_25
  • ID: 4h930ksd_2
    Snippet: Plau gene regulates polarization and bioelectric features of AT2 monolayers. The divergent bioelectric features in polarized AT2 monolayers, including transepithelial resistance (RT) and short-circuit currents (ISC) were measured. Plau -/monolayers showed a lower ISC level compared to wt monolayer and diminished significantly by replacing Na + -free bath solution to inhibit Na + ion transport (Fig. 3A-B) , consistent with our previous studies in .....
    Document: Plau gene regulates polarization and bioelectric features of AT2 monolayers. The divergent bioelectric features in polarized AT2 monolayers, including transepithelial resistance (RT) and short-circuit currents (ISC) were measured. Plau -/monolayers showed a lower ISC level compared to wt monolayer and diminished significantly by replacing Na + -free bath solution to inhibit Na + ion transport (Fig. 3A-B) , consistent with our previous studies in the airway epithelial cells27. Moreover, Plau -/-AT2 cells showed a reduced amiloridesensitive ISC level compared to wt cells (Fig. 3C-D) . However, the amiloride affinity was not altered significantly ( Fig. 3D) . In addition, a greater RTE value on day 5 was measured in wt monolayers compared to Plau -/monolayer cultures (Fig. 3E) . Thus, the ENaC activity seems to be regulated by the Plau gene.

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