Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_5
Snippet: High ISD can alleviate the problem of constraint. Amino acid substitutions that maintain disorder have a reasonable chance of being tolerated, in contrast to the relative fragility of a well-defined three-dimensional structure. This expectation is confirmed by the higher evolutionary rates observed for disordered proteins [4] , [13] . The known elevation of evolutionary constraint on overlapping genes is usually invoked as the sole [47] , [53] or.....
Document: High ISD can alleviate the problem of constraint. Amino acid substitutions that maintain disorder have a reasonable chance of being tolerated, in contrast to the relative fragility of a well-defined three-dimensional structure. This expectation is confirmed by the higher evolutionary rates observed for disordered proteins [4] , [13] . The known elevation of evolutionary constraint on overlapping genes is usually invoked as the sole [47] , [53] or at least dominant [36] explanation for their high ISD. Given the strength of the evidence for constraint [25] , [39] , [40] , [43] , we attribute to constraint, by a process of elimination, what cannot be explained by our other two hypotheses.
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