Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_57
Snippet: Given the strong influence of frame combined with support for the facilitate-birth hypothesis, we hypothesized that novel genes would be born more often into the +2 frame ( Figure 4A , green) because the intrinsically higher ISD of the +2 reading frame would facilitate high ISD in the novel gene and hence birth. Our dataset contained 41 phylogenetically independent overlapping pairs. Surprisingly, we found the opposite of our prediction: 31 of th.....
Document: Given the strong influence of frame combined with support for the facilitate-birth hypothesis, we hypothesized that novel genes would be born more often into the +2 frame ( Figure 4A , green) because the intrinsically higher ISD of the +2 reading frame would facilitate high ISD in the novel gene and hence birth. Our dataset contained 41 phylogenetically independent overlapping pairs. Surprisingly, we found the opposite of our prediction: 31 of the novel genes were in the +1 frame of their ancestral counterparts, while only 10 were in the +2 frame (p = 10 −3 , cumulative binomial distribution with trial success probability 0.5).
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