Author: Nicola F Fletcher; Luke W Meredith; Emma L Tidswell; Steven R Bryden; Daniel Gonçalves-Carneiro; Yasmin Chaudhry; Claire Shannon-Lowe; Michael A Folan; Daniella A Lefteri; Marieke Pingen; Dalan Bailey; Clive S McKimmie; Alan W Baird
Title: A novel antiviral formulation inhibits a range of enveloped viruses. Document date: 2020_3_30
ID: nly9vojr_79
Snippet: Following treatment of orf virus with ViroSAL, we observed a dissociation of the viral envelope from virions, with higher concentrations disrupting virion integrity and morphology. In agreement with the present study, fatty acids were found to affect the viral envelope, with high concentrations causing complete disintegration of viral particles (Thormar et al., 1987 , Thormar et al., 1994 . In agreement with the present study, previous studies ha.....
Document: Following treatment of orf virus with ViroSAL, we observed a dissociation of the viral envelope from virions, with higher concentrations disrupting virion integrity and morphology. In agreement with the present study, fatty acids were found to affect the viral envelope, with high concentrations causing complete disintegration of viral particles (Thormar et al., 1987 , Thormar et al., 1994 . In agreement with the present study, previous studies have also reported no antiviral effect of fatty acids on nonenveloped viruses (Thormar et al., 1987 , Churchward et al., 2018 , indicating that the antiviral mechanism of free fatty acids and ViroSAL may involve the viral envelope and we anticipate that to be due to a surfactant effect (Yoon et al., 2015 , Yoon et al., 2017 . the author/funder. All rights reserved. No reuse allowed without permission.
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