Author: Nicola F Fletcher; Luke W Meredith; Emma L Tidswell; Steven R Bryden; Daniel Gonçalves-Carneiro; Yasmin Chaudhry; Claire Shannon-Lowe; Michael A Folan; Daniella A Lefteri; Marieke Pingen; Dalan Bailey; Clive S McKimmie; Alan W Baird
Title: A novel antiviral formulation inhibits a range of enveloped viruses. Document date: 2020_3_30
ID: nly9vojr_90
Snippet: Orf virus (MRI-scab) was treated with a pH5.5 buffer (A), 0.5% ViroSAL (B) or 3% ViroSAL (C) for 2 minutes, and pH was restored to 7. Mock treated virions exhibited typical poxvirus morphology with a prominent outer envelope (A). Virions treated with a low concentration of ViroSAL (1%) displayed altered morphology and external envelope integrity was disrupted (arrows)(B). Virions treated with a high concentration of ViroSAL (3%) exhibited heterog.....
Document: Orf virus (MRI-scab) was treated with a pH5.5 buffer (A), 0.5% ViroSAL (B) or 3% ViroSAL (C) for 2 minutes, and pH was restored to 7. Mock treated virions exhibited typical poxvirus morphology with a prominent outer envelope (A). Virions treated with a low concentration of ViroSAL (1%) displayed altered morphology and external envelope integrity was disrupted (arrows)(B). Virions treated with a high concentration of ViroSAL (3%) exhibited heterogeneous morphology with extensive disruption of virion structure (arrows).
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