Author: May, Danielle G.; Martin-Sancho, Laura; Anschau, Valesca; Liu, Sophie; Chrisopulos, Rachel J.; Scott, Kelsey L.; Halfmann, Charles T.; Peña, Ramon DÃaz; Pratt, Dexter; Campos, Alexandre R.; Roux, Kyle J.
Title: A BioID-derived proximity interactome for SARS-CoV-2 proteins Cord-id: ncr4pkh5 Document date: 2021_9_21
ID: ncr4pkh5
Snippet: The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here we use BioID to map the SARS-CoV-2 virus-host interactome using human lung cancer derived A549 cells expressing individual SARS-CoV-2 viral proteins. Functional enrichment analyses reveale
Document: The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here we use BioID to map the SARS-CoV-2 virus-host interactome using human lung cancer derived A549 cells expressing individual SARS-CoV-2 viral proteins. Functional enrichment analyses revealed previously reported and unreported cellular pathways that are in association with SARS-CoV-2 proteins. We have also established a website to host the proteomic data to allow for public access and continued analysis of host-viral protein associations and whole-cell proteomes of cells expressing the viral-BioID fusion proteins. Collectively, these studies provide a valuable resource to potentially uncover novel SARS-CoV-2 biology and inform development of antivirals.
Search related documents:
Co phrase search for related documents- acute cardiac injury and adaptive innate: 1
Co phrase search for related documents, hyperlinks ordered by date