Covid-19 Sequelae in Working Age Patients. a Systematic Review

d'Ettorre, Gabriele; Cacciola, Elio Gentilini; Santinelli, Letizia; De Girolamo, Gabriella; Spagnolello, Ornella; Russo, Alessandro; Tarsitani, Lorenzo; Ciccozzi, Massimo; Mastroianni, Claudio M; d'Ettorre, Gabriella; Ceccarelli, Giancarlo

Despite the SARS-CoV-2 pandemic is not yet controlled, the post-covid-19 syndrome is already a challenging topic: long-term multiorgan sequelae, although increasingly described, have not yet been systematized. Since post-covid-19 syndrome can significantly impact both the working capacity and the relationship life of surviving patients, we performed a systematic review of the evidence published over the last year and currently available in medical literature search databases (MEDLINE/Pubmed) and searching clinical trial registries, to evaluate the available evidences among workers. From of 31 publications that initially matched inclusion criteria, 13 studies have been considered suitable for relevance and age of subjects. A wide range of patients (16-87%) have a post-Covid syndrome; pneumological and neuropsychological symptoms were the most common disorders reported. The most frequent organic sequela found in post-Covid patients was the pulmonary fibrosis. Number of symptoms during acute SARS-CoV-2 infection, severity of the disease, and high serum levels of D-dimer were related with high risk of post-Covid syndrome. In conclusions, post-Covid-19 syndrome can significantly impact the health conditions of surviving patients. Rehabilitation and follow-up in multi-disciplinary rehabilitation programs should be considered for working-age patients. This article is protected by copyright. All rights reserved.