Author: Joseph T. Wu; Corey M. Peak; Gabriel M. Leung; Marc Lipsitch
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_5_14
ID: ejqq2wmi_44
Snippet: and other factors vary. The existence of a high-transmission season might enhance the benefits 312 of fractional-dose vaccination. Most importantly, there will be a premium on achieving high 313 vaccine coverage before the peak of transmission to maximally impact transmission, and this 314 will be limited by supply constraints that could be partially relieved by fractionation. Systematic review 438 We searched PubMed and Google Scholar on June 10.....
Document: and other factors vary. The existence of a high-transmission season might enhance the benefits 312 of fractional-dose vaccination. Most importantly, there will be a premium on achieving high 313 vaccine coverage before the peak of transmission to maximally impact transmission, and this 314 will be limited by supply constraints that could be partially relieved by fractionation. Systematic review 438 We searched PubMed and Google Scholar on June 10, 2016, with the terms "yellow fever" and 439 "vaccine" or "dose sparing". We did not find any reports of randomized trials of yellow fever 440 (YF) vaccine efficacy, at full or lower doses. Three relatively recent studies suggest similar 441 immunological responses at five-fold, or more, fractionation as compared to the current dose 442 antigen levels. 8, 9, 27 While several recent perspective articles propose the dose-sparing strategy 443
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