Author: Nathalie Pamir; Calvin Pan; Deanna L. Plubell; Patrick M. Hutchins; Chongren Tang; Jake Wimberger; Angela Irwin; Thomas Q. de Aguiar Vallim; Jay W. Heinecke; Aldons J. Lusis
Title: Genetic control of the HDL proteome Document date: 2018_8_31
ID: hx7n4xfo_27_1
Snippet: with all the efflux measures. While we captured strong associations between expected metrics such as diffusional or ABCA1 specific efflux from two different cell types, no single HDL protein explained the majority of the variation in sterol efflux, suggesting that it is a polygenic process. That said, APOA2 explained about 10% of ABCA1 dependent sterol efflux from both cell types and the Apoa2 locus was strongly associated with ABCA1 specific ste.....
Document: with all the efflux measures. While we captured strong associations between expected metrics such as diffusional or ABCA1 specific efflux from two different cell types, no single HDL protein explained the majority of the variation in sterol efflux, suggesting that it is a polygenic process. That said, APOA2 explained about 10% of ABCA1 dependent sterol efflux from both cell types and the Apoa2 locus was strongly associated with ABCA1 specific sterol efflux (data not shown). In mice, APOA2 seems to impact the sterol efflux function at the protein and gene level. It is important to note that Apoa2 locus aligns with HDL-C QTL.
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