Author: Nicola F Fletcher; Luke W Meredith; Emma L Tidswell; Steven R Bryden; Daniel Gonçalves-Carneiro; Yasmin Chaudhry; Claire Shannon-Lowe; Michael A Folan; Daniella A Lefteri; Marieke Pingen; Dalan Bailey; Clive S McKimmie; Alan W Baird
Title: A novel antiviral formulation inhibits a range of enveloped viruses. Document date: 2020_3_30
ID: nly9vojr_35
Snippet: Because arbovirus infection of the skin always occurs in the context of an arthropod bite, we used a mouse model that additionally incorporates biting Aedes aegypti mosquitoes. Host response to mosquito bites includes oedema and an influx of leukocytes that enhances host susceptibility to infection with virus (Pingen et al., 2016) . Therefore, we used our previously established model of arbovirus infection at mosquito bites. This model was specif.....
Document: Because arbovirus infection of the skin always occurs in the context of an arthropod bite, we used a mouse model that additionally incorporates biting Aedes aegypti mosquitoes. Host response to mosquito bites includes oedema and an influx of leukocytes that enhances host susceptibility to infection with virus (Pingen et al., 2016) . Therefore, we used our previously established model of arbovirus infection at mosquito bites. This model was specifically developed to model natural infection by arbovirus, including mimicking the same dose delivered by mosquitoes, using mosquito cell-derived virus, injecting a small 1ul inoculum volume, and by including the presence of a mosquito bite at the site of inoculation. To ensure that mosquitoes the author/funder. All rights reserved. No reuse allowed without permission.
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