COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

Xu, Zhaowei; Li, Yang; Lei, Qing; Huang, Likun; Lai, Dan-yun; Guo, Shu-juan; Jiang, He-wei; Hou, Hongyan; Zheng, Yun-xiao; Wang, Xue-ning; Wu, Jiaoxiang; Ma, Ming-liang; Zhang, Bo; Chen, Hong; Yu, Caizheng; Xue, Jun-biao; Zhang, Hai-nan; Qi, Huan; Yu, Siqi; Lin, Mingxi; Zhang, Yandi; Lin, Xiaosong; Yao, Zongjie; Sheng, Huiming; Sun, Ziyong; Wang, Feng; Fan, Xionglin; Tao, Sheng-ce

Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, differences in immune responses and clinical features among COVID-19 patients remain largely unknown. Here, we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters (COVID-ONE humoral immune). COVID-ONE humoral immunity is based on a dataset that contains the IgG/IgM responses to 21 of 28 known SARS-CoV-2 proteins and 197 spike protein peptides against 2,360 COVID-19 samples collected from 783 patients. In addition, 96 clinical parameters for the 2,360 samples and information for the 783 patients are integrated into the database. Furthermore, COVID-ONE humoral immune provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups. A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters. After the “START” button is clicked, one can readily obtain a comprehensive analysis report for further interpretation. COVID-ONE-humoral immune is freely available at www.COVID-ONE.cn.