Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_11
Snippet: Artifact of the Here we test the predictions of all three hypotheses, as summarized in Figure 1 , and find that both the birthfacilitation and conflict-resolution hypotheses play a role. The artifact hypothesis plays no appreciable role in elevating the ISD of overlapping regions; while reading frame (+1 vs. +2) strongly affects the ISD of individual genes, each overlapping gene pair has one of each, and the two cancel out such that there is no n.....
Document: Artifact of the Here we test the predictions of all three hypotheses, as summarized in Figure 1 , and find that both the birthfacilitation and conflict-resolution hypotheses play a role. The artifact hypothesis plays no appreciable role in elevating the ISD of overlapping regions; while reading frame (+1 vs. +2) strongly affects the ISD of individual genes, each overlapping gene pair has one of each, and the two cancel out such that there is no net contribution to the high ISD found in overlapping regions. Surprisingly, novel genes are more likely to be born in the frame prone to lower ISD; this seems to be a case where mutation bias in the availability of open reading frames (ORFs) is more important than selection favoring higher ISD for novel than ancestral genes.
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