Author: Jing, Hongwu; Ackerman, William E.; Zhao, Guomao; El Helou, Yara; Buhimschi, Catalin S.; Buhimschi, Irina A.
Title: Connecting the Dots on Vertical Transmission SARS-CoV-2 Using Protein-Protein Interaction Network Analysis – Potential roles of placental ACE2 and ENDOU Cord-id: oke224mq Document date: 2020_11_9
ID: oke224mq
Snippet: We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2, and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus
Document: We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2, and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU’s relevance to vertical transmission of SARS-CoV-2 is further warranted.
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