Selected article for: "deletion mutant and steady state"
Author: Mélanie Legrand; Sophie Bachellier-Bassi; Keunsook K. Lee; Yogesh Chaudhari; Hélène Tournu; Laurence Arbogast; Hélène Boyer; Murielle Chauvel; Vitor Cabral; Corinne Maufrais; Audrey Nesseir; Irena Maslanka; Emmanuelle Permal; Tristan Rossignol; Louise A. Walker; Ute Zeidler; Sadri Znaidi; Floris Schoeters; Charlotte Majgier; Renaud A. Julien; Laurence Ma; Magali Tichit; Christiane Bouchier; Patrick Van Dijck; Carol A. Munro; Christophe d’Enfert
Title: Generating genomic platforms to study Candida albicans pathogenesis
  • Document date: 2018_2_8
    • ID: 1vx62ofn_4
    Snippet: Nowadays, the growing availability of whole-genome datasets has encouraged a shift towards the development of functional genomics and systems biology, enabling analysis of highthroughput whole-genome assays to better understand biological networks. In this context, major efforts have been made to generate large-scale deletion (6) (7) (8) (9) or overexpression (10) (11) (12) mutant collections. Genome-wide ORF libraries or ORFeomes represent usefu.....
    Document: Nowadays, the growing availability of whole-genome datasets has encouraged a shift towards the development of functional genomics and systems biology, enabling analysis of highthroughput whole-genome assays to better understand biological networks. In this context, major efforts have been made to generate large-scale deletion (6) (7) (8) (9) or overexpression (10) (11) (12) mutant collections. Genome-wide ORF libraries or ORFeomes represent useful resources for the implementation of approaches used to elucidate gene function (13) . Besides the development of collections of overexpression mutants (11) , ORFeomes facilitate approaches aimed at evaluating protein subcellular localization and identifying protein-protein interactions (yeast two-hybrid) both at steady state and in response to environmental stimuli (14) .

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