Author: Enrico Lavezzo; Michele Berselli; Ilaria Frasson; Rosalba Perrone; Giorgio Palù; Alessandra R. Brazzale; Sara N. Richter; Stefano Toppo
Title: G-quadruplex forming sequences in the genome of all known human viruses: a comprehensive guide Document date: 2018_6_11
ID: c3lmmll6_65
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/344127 doi: bioRxiv preprint the minimum number of G in every G-island of a G4 and 'd' is the maximum distance allowed between two consecutive G-islands, the following combinations of 'l' and 'd' were searched: l = 2 and d = 7; l = 3 and d = 12; l = 4 and d = 12. Patterns in the negative strands of viral genomes were searched by looking for cytos.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/344127 doi: bioRxiv preprint the minimum number of G in every G-island of a G4 and 'd' is the maximum distance allowed between two consecutive G-islands, the following combinations of 'l' and 'd' were searched: l = 2 and d = 7; l = 3 and d = 12; l = 4 and d = 12. Patterns in the negative strands of viral genomes were searched by looking for cytosines (Cs) instead of Gs. The conservation of each G4 in the multiple aligned genomes of the viruses was determined by looking at the conservation not only of the G-islands but also their connecting loops. We computed different indexes to measure the nucleotide sequence conservation of viral genomes and G4s:
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