Author: Neha Jain; Subodh Kumar Mishra; Uma Shankar; Arpita Tawani; Ankit Jaiswal; Tarun Kumar Sharma; Prashant Kodgire; Amit Kumar
Title: G-quadruplex stabilization in the ions and maltose transporters inhibit Salmonella enterica growth and virulence Document date: 2018_6_27
ID: 57xx291v_6
Snippet: The bacteria contain three genes that help in Mg 2+ uptake from the host namely: i) mgtA, ii) mgtB, and iii) corA. Neutralization of the reactive nitrogen stress(RNS, nitro-oxidative) is mainly regulated by Mg 2+ transport ATPase that is encoded by mgtA gene and therefore plays a vital role in the bacterial survival inside macrophage (Fig 2a) [22] . Hence, targeting the conserved region of mgtA gene may serve as a promising therapeutic approach t.....
Document: The bacteria contain three genes that help in Mg 2+ uptake from the host namely: i) mgtA, ii) mgtB, and iii) corA. Neutralization of the reactive nitrogen stress(RNS, nitro-oxidative) is mainly regulated by Mg 2+ transport ATPase that is encoded by mgtA gene and therefore plays a vital role in the bacterial survival inside macrophage (Fig 2a) [22] . Hence, targeting the conserved region of mgtA gene may serve as a promising therapeutic approach to combat with S. enterica pathogenesis.
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