Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_62
Snippet: The study of overlapping genes has of course its own statistical traps. In particular, the preponderance of novel genes in the +1 frame demonstrates the need to control for the strong effects of frame when testing hypotheses. Ancestral genes are more frequently in the high-ISD +2 frame, while the depressed ISD of the +1 frame lowers the ISD of the novel. As a result, when frame is not considered, ancestral and novel overlapping sequences encode v.....
Document: The study of overlapping genes has of course its own statistical traps. In particular, the preponderance of novel genes in the +1 frame demonstrates the need to control for the strong effects of frame when testing hypotheses. Ancestral genes are more frequently in the high-ISD +2 frame, while the depressed ISD of the +1 frame lowers the ISD of the novel. As a result, when frame is not considered, ancestral and novel overlapping sequences encode very similar levels of disorder (0.41 ± 0.03 vs. 0.42 ± 0.04, respectively), making it easy to miss the evidence for the facilitatebirth hypothesis.
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