Author: Arokiaraj, M. C.; Menesson, E.
Title: Rose exctracts and in-vitro inhibition of SARS-CoV-2 spike: The ACE-2 interaction Cord-id: amberqoj Document date: 2021_1_1
ID: amberqoj
Snippet: Objective: The study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. Methods: ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was assessed in a dose-dependent sequence. Results: The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% in
Document: Objective: The study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. Methods: ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was assessed in a dose-dependent sequence. Results: The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extracts to the lower respiratory tract and pulmonary tissues. Conclusion: Rose extracts have a potential for inhibition of SARS-CoV-2 and ACE2 receptor in vitro, which could add beneficial effects in Covid-19 treatment. Further tests need to be performed to study their therapeutic benefits in vivo.
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