Selected article for: "de novo gene birth and gene birth"
Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes
  • Document date: 2017_12_6
    • ID: 9w2wjiik_49
    Snippet: In agreement with the conflict resolution hypothesis, ancestral overlapping sequences, not just novel ones, have higher ISD than non-overlapping genes (0.35 ± 0.02 vs. 0.25 ± 0.01 ; p = 2 × 10 −5 ). This seems to be because ISD was already high at the time of de novo gene birth; today's ancestral overlapping genes have indistiguishable ISD from their pre-overlapping homologs (p = 0.6), while those pre-overlapping homologs have higher ISD tha.....
    Document: In agreement with the conflict resolution hypothesis, ancestral overlapping sequences, not just novel ones, have higher ISD than non-overlapping genes (0.35 ± 0.02 vs. 0.25 ± 0.01 ; p = 2 × 10 −5 ). This seems to be because ISD was already high at the time of de novo gene birth; today's ancestral overlapping genes have indistiguishable ISD from their pre-overlapping homologs (p = 0.6), while those pre-overlapping homologs have higher ISD than non-overlapping genes (p= 2 × 10 −3 ) ( Figure 4B ).

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