Author: Manabe, Yukari C; Reuland, Carolyn; Yu, Tong; Azamfirei, Razvan; Church, Taylor; Brown, Diane M; Sewell, Thelio T; Hardick, Justin P; Blair, Paul W; Heaney, Christopher D; Pekosz, Andrew; Thomas, David L
Title: Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection. Cord-id: pkx2yzkd Document date: 2020_10_12
ID: pkx2yzkd
Snippet: In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid sample pairs by RT-PCR. Nasal-oropharyngeal swabs were more sensitive than this salivary sample type (oral crevicular fluid) suggesting that not all saliva sample types have equivalent sensitivity. However, all samples that were Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) were also oral fluid RT-P
Document: In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid sample pairs by RT-PCR. Nasal-oropharyngeal swabs were more sensitive than this salivary sample type (oral crevicular fluid) suggesting that not all saliva sample types have equivalent sensitivity. However, all samples that were Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) were also oral fluid RT-PCR positive suggesting that oral fluid may find the patients most likely to transmit disease to others.
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