Author: Yánez, Diana C.; Ross, Susan; Crompton, Tessa
Title: The IFITM protein family in adaptive immunity Cord-id: 8wg41v6m Document date: 2019_12_22
ID: 8wg41v6m
Snippet: Interferonâ€inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1–IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1–3, IFITM6). IFITM1–3 are expressed by T cells and recent experi
Document: Interferonâ€inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1–IFITM3), osteoblast function and bone mineralization (IFITM5) and immune functions (IFITM1–3, IFITM6). IFITM1–3 are expressed by T cells and recent experiments have shown that the IFITM proteins are directly involved in adaptive immunity and that they regulate CD4(+) T helper cell differentiation in a Tâ€cellâ€intrinsic manner. Here we review the role of the IFITM proteins in Tâ€cell differentiation and function.
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