Author: Liu, Xinsheng; Lin, Chun-Ming; Annamalai, Thavamathi; Gao, Xiang; Lu, Zhongyan; Esseili, Malak A; Jung, Kwonil; El-Tholoth, Mohamed; Saif, Linda J; Wang, Qiuhong
Title: Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strain Cord-id: 72a9dvsr Document date: 2015_9_25
ID: 72a9dvsr
Snippet: The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD(50)) of the virus pool was determined as 7.35 log(10) PDD(50)/mL, similar to the cell culture infectious titer, 7.75 log(10) plaque-forming units (PFU)/mL. 100 PDD(50) caused watery diarrhea in all conventional suckling piglets (n = 12) derived from a PEDV-naive sow, whereas 1000 and 10 000 PDD(50) did not cause d
Document: The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD(50)) of the virus pool was determined as 7.35 log(10) PDD(50)/mL, similar to the cell culture infectious titer, 7.75 log(10) plaque-forming units (PFU)/mL. 100 PDD(50) caused watery diarrhea in all conventional suckling piglets (n = 12) derived from a PEDV-naive sow, whereas 1000 and 10 000 PDD(50) did not cause diarrhea in piglets derived from two PEDV-field exposed-recovered sows. This information is important for future PEDV challenge studies and validation of PEDV vaccines.
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