Author: Nathalie Pamir; Calvin Pan; Deanna L. Plubell; Patrick M. Hutchins; Chongren Tang; Jake Wimberger; Angela Irwin; Thomas Q. de Aguiar Vallim; Jay W. Heinecke; Aldons J. Lusis
Title: Genetic control of the HDL proteome Document date: 2018_8_31
ID: hx7n4xfo_2
Snippet: To better define the various species of HDL at the level of protein composition and to understand their genetic regulation we used the Hybrid Mouse Diversity Panel (HMDP) with a systems biology approach (Bennett et al., 2010; Ghazalpour et al., 2012) . HMDP is a collection of 100 classical laboratory and recombinant inbred (RI) strains that have been genotyped at 135,000 SNPs (Bennett et al., 2010) . HMDP provides a confined genetic space (Bennet.....
Document: To better define the various species of HDL at the level of protein composition and to understand their genetic regulation we used the Hybrid Mouse Diversity Panel (HMDP) with a systems biology approach (Bennett et al., 2010; Ghazalpour et al., 2012) . HMDP is a collection of 100 classical laboratory and recombinant inbred (RI) strains that have been genotyped at 135,000 SNPs (Bennett et al., 2010) . HMDP provides a confined genetic space (Bennett et al., 2010) that rely on naturally occurring genetic variation that perturbs protein abundance. We performed systems genetics approach using analytical approaches that include genome-wide association, expression quantitative trait locus (eQTL) discovery, functional outcomes and network analysis (Bennett et al., 2010) .
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