Author: Nathalie Pamir; Calvin Pan; Deanna L. Plubell; Patrick M. Hutchins; Chongren Tang; Jake Wimberger; Angela Irwin; Thomas Q. de Aguiar Vallim; Jay W. Heinecke; Aldons J. Lusis
Title: Genetic control of the HDL proteome Document date: 2018_8_31
ID: hx7n4xfo_34
Snippet: Jay Heinecke is named as a co-inventor on patents from the US Patent Office on the use of HDL markers to predict the risk of cardiovascular disease. Dr. Heinecke has served as a consultant for Kowa, Merck, Amgen, Bristol Meyer Squibb, GSK, and Pacific Biomarkers. . Hierarchical clustering of the HDL metrics: Proteome, sterol efflux, particle concentration and size. min.MF, plus.MF, delta.BHK are unstimulated, ABCA1 upregulated and ABCA1 specific .....
Document: Jay Heinecke is named as a co-inventor on patents from the US Patent Office on the use of HDL markers to predict the risk of cardiovascular disease. Dr. Heinecke has served as a consultant for Kowa, Merck, Amgen, Bristol Meyer Squibb, GSK, and Pacific Biomarkers. . Hierarchical clustering of the HDL metrics: Proteome, sterol efflux, particle concentration and size. min.MF, plus.MF, delta.BHK are unstimulated, ABCA1 upregulated and ABCA1 specific sterol efflux from BHK cells respectively. min.cAMP, plus.cAMP, delta.J774 are unstimulated, ABCA1 upregulated and ABCA1 specific sterol efflux from J774 cells respectively. m.hdl.size and l.hdl.size are medium and large HDL sizes respectively. The correlation structure was determined using pearson correlation. The protein functional groups were curated from DAVID, KEGG, Panther, and Uniprot databases. Figure 1 . Self-loops were removed and edges were bundled for clarity. Node locations are assigned using an edge-weighted spring-embedded layout algorithm using the negative log of the Benjamini-Hochberg corrected p-value, and edge transparency is directly proportional to the same value. Red: negative correlation, Blue: positive correlation. Shorter distances indicate stronger correlations.
Search related documents:
Co phrase search for related documents- Benjamini Hochberg negative log and correlation structure: 1
- Benjamini Hochberg negative log and edge transparency: 1
- Benjamini Hochberg negative log and hierarchical clustering: 1
- Benjamini Hochberg negative log and large medium HDL size: 1
- Benjamini Hochberg negative log and layout algorithm: 1
- Benjamini Hochberg negative log and MF delta: 1
- Benjamini Hochberg negative log and negative correlation: 1
- Benjamini Hochberg negative log and negative log: 1
- Benjamini Hochberg negative log and particle concentration: 1
- Benjamini Hochberg negative log and pearson correlation: 1
- Benjamini Hochberg negative log and positive correlation: 1
- Benjamini Hochberg negative log and respectively large medium HDL size: 1
- Benjamini Hochberg negative log and size particle concentration: 1
- Benjamini Hochberg negative log and size particle concentration sterol efflux: 1
- Benjamini Hochberg negative log and size particle concentration sterol efflux proteome: 1
- Benjamini Hochberg negative log and sterol efflux: 1
- Benjamini Hochberg negative log layout algorithm and blue negative correlation: 1
- Benjamini Hochberg negative log layout algorithm and correlation structure: 1
- Benjamini Hochberg negative log layout algorithm and edge transparency: 1
Co phrase search for related documents, hyperlinks ordered by date