Author: Cazzaniga, Massimo; Fumagalli, Luca A. M.; D'angelo, Luciano; Cerino, Mario; Bonfanti, Giulia; Fumagalli, Riccardo M.; Schiavo, Gianpaolo; Lorini, Cristina; Lainu, Elisa; Terragni, Sabina; Chiarelli, Marco; Scarazzati, Claudio; Bonato, Claudio; Zago, Mauro
Title: Eosinopenia is a reliable marker of severe disease and unfavourable outcome in patients with COVIDâ€19 pneumonia Cord-id: ezqjw8jq Document date: 2021_2_5
ID: ezqjw8jq
Snippet: BACKGROUND AND AIM: Viral pneumonia is the most relevant clinical presentation of COVIDâ€19 which may lead to severe acute respiratory syndrome and even death. Eosinopenia was often noticed in patients with COVIDâ€19 pneumonia, but its role is poorly investigated. The aim of the present study was to investigate the characteristics and clinical outcomes of patients with COVIDâ€19 pneumonia and eosinopenia. METHODS: We revised the records of consecutive patients with COVIDâ€19 pneumonia admitt
Document: BACKGROUND AND AIM: Viral pneumonia is the most relevant clinical presentation of COVIDâ€19 which may lead to severe acute respiratory syndrome and even death. Eosinopenia was often noticed in patients with COVIDâ€19 pneumonia, but its role is poorly investigated. The aim of the present study was to investigate the characteristics and clinical outcomes of patients with COVIDâ€19 pneumonia and eosinopenia. METHODS: We revised the records of consecutive patients with COVIDâ€19 pneumonia admitted to our ERâ€COVIDâ€19 area in order to compare clinical characteristics and outcomes of patients with and without eosinopenia. We considered the following clinical outcomes: 4â€weeks survival; need for intensive respiratory support; and hospital discharge. RESULTS: Out of first 107 consecutive patients with pneumonia and a positive COVIDâ€19 nasopharyngeal swab, 75 patients showed undetectable eosinophil count (absolute eosinopenia). At 4 weeks, 38 patients (38.4%) had required intensive respiratory treatment, 25 (23.4%) deceased and 42 (39.2%) were discharged. Compared with patients without absolute eosinopenia, patients with absolute eosinopenia showed higher need of intensive respiratory treatment (49.3% vs 13.3%, P < .001), higher mortality (30.6% vs 6.2%, P .006) and lower rate of hospital discharge (28% vs 65.6%, P < .001). Binary logistic regression analyses including neutrophil, lymphocyte, eosinophil, basophil and monocyte counts showed that absolute eosinopenia was an independent factor associated with 4â€weeks mortality, need for intensive respiratory support and hospital discharge. CONCLUSIONS: Absolute eosinopenia is associated with clinical outcomes in patients with COVIDâ€19 pneumonia and might be used as a marker to discriminate patients with unfavourable prognosis.
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