Author: Joseph T. Wu; Corey M. Peak; Gabriel M. Leung; Marc Lipsitch
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_5_14
ID: ejqq2wmi_18
Snippet: Infection attack rate 157 We use IAR as the outcome measure for evaluating the impact of dose fractionation. We 158 calculate IAR using the classical final size approach which is exact for directly transmitted SIR-159 type diseases 19 but only an approximation for vector-borne diseases. 20 Nonetheless, this 160 dose vaccines will be given to children aged between 9 months and 2 years (which is 202 sufficient for vaccinating all unvaccinated child.....
Document: Infection attack rate 157 We use IAR as the outcome measure for evaluating the impact of dose fractionation. We 158 calculate IAR using the classical final size approach which is exact for directly transmitted SIR-159 type diseases 19 but only an approximation for vector-borne diseases. 20 Nonetheless, this 160 dose vaccines will be given to children aged between 9 months and 2 years (which is 202 sufficient for vaccinating all unvaccinated children in this age range) and the remaining 203 allocation will be fractionated to one-fifth of the standard dose and given to the rest of 204 the population. We compare the outcome when the vaccines are administered (i) in 205 standard dose only (strategy S) and (ii) according to the WHO dose-sparing strategy with 206 alternative age cutoffs for fractional-dose vaccines ranging from 2 to 20 years (strategy 207 F). For the latter, let Z be the age cutoff and ( ) p Z be the proportion of population 208 targeted for standard-dose vaccination. For a given standard-dose vaccine coverage V , 209 the proportion of population receiving standard-dose and fractional-dose vaccines are 210
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