Author: Mohammad Saeed; Alejandro Ibáñez-Costa; Alejandra María Patiño-Trives; Eduardo Collantes Estevez; María Ángeles Aguirre; Chary López-Pedrera
Title: Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene Document date: 2020_4_18
ID: 27szdvgd_11
Snippet: and TTC9 (Table 1) . DDX11, located in OASIS locus 19 on chromosome 12, was downregulated, however it did not cross the FDR for expression. In the Cordoba expression dataset, GSE50395, 518 genes were found to have differential expression. Of these 10 genes were found in the reference list of 410 genes in OASIS SLE loci (Table 2 ). BARHL1 had the most significant expression change (P=8.9 x 10 -5 ) and DDX11 had the second highest expression chan.....
Document: and TTC9 (Table 1) . DDX11, located in OASIS locus 19 on chromosome 12, was downregulated, however it did not cross the FDR for expression. In the Cordoba expression dataset, GSE50395, 518 genes were found to have differential expression. Of these 10 genes were found in the reference list of 410 genes in OASIS SLE loci (Table 2 ). BARHL1 had the most significant expression change (P=8.9 x 10 -5 ) and DDX11 had the second highest expression change (P=8 x 10 -3 ).
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