Selected article for: "linkage method and sample size"
Author: Mohammad Saeed; Alejandro Ibáñez-Costa; Alejandra María Patiño-Trives; Eduardo Collantes Estevez; María Ángeles Aguirre; Chary López-Pedrera
Title: Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene
  • Document date: 2020_4_18
    • ID: 27szdvgd_3
    Snippet: OASIS is a linkage disequilibrium (LD) clustering method that can be used to mine existing complex disease GWAS datasets for new genes (Saeed, 2017b , Saeed, 2018 . OASIS provides an alternative to increasing sample size for GWAS by composite analysis unifying two aspects of the LD phenomenon -strength of association and number of surrounding significant SNPs. A genomic convergence approach (Liang et al., 2009 ) mapping genetic association signal.....
    Document: OASIS is a linkage disequilibrium (LD) clustering method that can be used to mine existing complex disease GWAS datasets for new genes (Saeed, 2017b , Saeed, 2018 . OASIS provides an alternative to increasing sample size for GWAS by composite analysis unifying two aspects of the LD phenomenon -strength of association and number of surrounding significant SNPs. A genomic convergence approach (Liang et al., 2009 ) mapping genetic association signals on expression data and other biological studies can then be used for verification of particular genes.

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