Selected article for: "diagnostic test and low sensitivity"
Author: Thirion-Romero, Dr. Ireri; Guerrero-Zúñiga, Dr. Selene; Arias-Mendoza, Dr. Alexandra; Cornejo-Juárez, Dr. Dora Patricia; Meza-Meneses, Dr. Patricia; Torres-Erazo, Dr. Darwin Stalin; Hernández, Dr. Thierry; Galindo-Fraga, Dr. Arturo; Villegas-Mota, Dr. Isabel; Sepúlveda-Delgado, Dr. Jesús; Ávila-Ríos, Dr. Santiago; Becerril-Vargas, Dr. Eduardo; Fernández-Plata, Rosario; Pérez-Kawabe, TIT Midori; Coeto-Cano, Dra. Ana; Vázquez-Pérez, Dr. Joel Armando; Kawa-Karasik, Dr. Simón; Reyes-Terán, Dr. Gustavo; Pérez-Padilla, Dr. José Rogelio
Title: EVALUATION OF PANBIO RAPID ANTIGEN TEST FOR SARS-CoV-2 IN SYMPTOMATIC PATIENTS AND THEIR CONTACTS: A MULTICENTER STUDY
  • Cord-id: f3smudd5
  • Document date: 2021_10_20
    • ID: f3smudd5
    Snippet: BACKGROUND Point-of-care rapid tests to identify SARS-CoV-2 can be of great clinical help. METHODS A cross sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19, to define the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott´s Panbio™) performed by health personnel in a routine situation during an outbreak, compared with the RT-PCR for SARS-CoV-2. RESULTS A total of 1,060 participants (mean age of 47 years, 47% with a
    Document: BACKGROUND Point-of-care rapid tests to identify SARS-CoV-2 can be of great clinical help. METHODS A cross sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19, to define the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott´s Panbio™) performed by health personnel in a routine situation during an outbreak, compared with the RT-PCR for SARS-CoV-2. RESULTS A total of 1,060 participants (mean age of 47 years, 47% with a self-reported comorbidity) recruited from eight hospitals in Mexico provided 1060 valid rapid test-RT-PCR test pairs with a prevalence of a positive RT-PCR test of 45%. Overall sensitivity of the Panbio test was 54.2% (95%CI 51-57) and for patients during the first week of symptoms was 69.1% (95%CI 66-73). Sensitivity depended on viral load (Cycle threshold of RT-PCR, Ct), and the days of symptoms. With a Ct≤25, sensitivity was 82% (95%CI, 76-87%). On the other hand, specificity of the rapid test was above 97.8% in all groups. CONCLUSIONS The PanbioTM rapid antigen test for SARS-CoV-2 had a good specificity, but a low sensitivity in real life, and a negative test requires confirmation with RT-PCR, especially after the first week of symptoms.

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