Selected article for: "antigen delivery and delivery system"
Author: Zhao, Guangzu; Chandrudu, Saranya; Skwarczynski, Mariusz; Toth, Istvan
Title: The application of self-assembled nanostructures in peptide-based subunit vaccine development
  • Cord-id: r077ybzg
  • Document date: 2017_2_10
    • ID: r077ybzg
    Snippet: Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to m
    Document: Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.

    Search related documents:
    Co phrase search for related documents
    • acute respiratory syndrome and additional complexity: 1, 2
    • acute respiratory syndrome and adjuvant alum: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute respiratory syndrome and long carry: 1
    • acute respiratory syndrome and long lipid: 1
    • acute respiratory syndrome and long peptide: 1, 2, 3, 4, 5, 6
    • acute respiratory syndrome and long term protection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25