Author: Amir Saberi; Anastasia A. Gulyaeva; John L. Brubacher; Phillip A. Newmark; Alexander E. Gorbalenya
Title: A planarian nidovirus expands the limits of RNA genome size Document date: 2018_4_11
ID: gwgflckq_8
Snippet: The enzymatic domains contain most essential catalytic residues, suggesting that they retain canonical functions, although notable deviations were also observed (Figs. S7-S14). Unique features of PSCNV's putative enzymes include: a) 3CLpro encodes a valine (Val) residue in the position commonly occupied by a His residue in the putative substrate-binding pocket (GXV vs G/YXH) that controls the P1 substrate preference for Glu or glutamine (Gln) res.....
Document: The enzymatic domains contain most essential catalytic residues, suggesting that they retain canonical functions, although notable deviations were also observed (Figs. S7-S14). Unique features of PSCNV's putative enzymes include: a) 3CLpro encodes a valine (Val) residue in the position commonly occupied by a His residue in the putative substrate-binding pocket (GXV vs G/YXH) that controls the P1 substrate preference for Glu or glutamine (Gln) residues (31-35); b) a Ser residue of the nidovirus-specific SDD signature of RdRp (12) is replaced by glycine (Gly)a characteristic of ssRNA+ viruses other than nidoviruses; c) the invariant aspartate (Asp), along with the highly conserved Ser/Thr, of motif B N of the NiRAN (29) are substituted with Thr and Asn, respectively; d) four Cys/His residues coordinating a Zn 2+ in the active site of ExoN (16, 17) are replaced in PSCNV, which, like non-nidoviral homologs , apparently lacks this Zn-finger.
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