A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: a possible reason underlying different outcome between gender.

Fanfan Zeng; Chan Dai; Pengcheng Cai; Jinbiao Wang; Lei Xu; Jianyu Li; Guoyun Hu; Lin Wang

To clarify the dynamic change of IgG antibody in male and female patients, we analyzed the level of IgG antibody between male and female patients in those four disease status. As shown in Figure 1A , in female patients, the level of IgG antibody continuously increased from mild status patients to general patients and severe patients, and then decreased in recovering patients. While in male patients, the IgG antibody raised from mild status patients to general patients, and then decreased from severe patients to recovering patients. In addition to severe status, the level of IgG antibody in the other three statuses were nearly the same. While in severe status, compared with male patients, the level of IgG antibody in severe status seemed to be higher in female patients. Next, we mapped scatter diagrams respectively for the above four status of patients. However, none of these four status showed a statistical difference in IgG antibody level between male and female patients ( Figure 1B-1E) . Notably, in severe status, most of the female patients had an antibody level for more than 100AU/mL, while in male patients, most of the IgG antibody were under 100AU/mL. Together, above data showed that the SARS-CoV-2 IgG level in female patients seemed to be higher than that of in male patients in severe status.