Author: Maharaj, Satish; Xue, Ruobing; Rojan, Adam
Title: Thrombotic thrombocytopenic purpura (TTP) response following COVID-19 infection: implications for the ADAMTS13-von Willebrand factor axis. Cord-id: 7992qa54 Document date: 2020_12_31
ID: 7992qa54
Snippet: One of the most prominent hematologic effects of infection with coronavirus disease 2019 (COVID-19) is increased thrombotic risk. The mechanisms of this hypercoagulable state, which defies even therapeutic anticoagulation, are under intense investigation. Autopsy studies have confirmed thrombotic disease not only at the macrovascular scale (pulmonary emboli, venous thromboses) but also with microthrombi in alveolar capillaries and severe endothelial injury. Several studies have reported elevated
Document: One of the most prominent hematologic effects of infection with coronavirus disease 2019 (COVID-19) is increased thrombotic risk. The mechanisms of this hypercoagulable state, which defies even therapeutic anticoagulation, are under intense investigation. Autopsy studies have confirmed thrombotic disease not only at the macrovascular scale (pulmonary emboli, venous thromboses) but also with microthrombi in alveolar capillaries and severe endothelial injury. Several studies have reported elevated levels of von Willebrand Factor (VWF) activity, VWF antigen, and factor VIII levels in COVID-19, and incremental increases are reported with severity of disease.
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