Author: Huang, Kai; Wang, Catherine; Vagts, Christen; Raguveer, Vanitha; Finn, Patricia W.; Perkins, David L.
Title: LncRNAs NEAT1 and MALAT1 Differentiate Inflammation in Severe COVID-19 Patients Cord-id: ku9rups0 Document date: 2021_3_29
ID: ku9rups0
Snippet: Hyperactive and damaging inflammation is a hallmark of severe rather than mild COVID-19 syndrome. To uncover key inflammatory differentiators between severe and mild COVID-19 disease, we applied an unbiased single-cell transcriptomic analysis. We integrated a bronchoalveolar lavage (BAL) dataset with a peripheral blood mononuclear cell dataset (PBMC) and analyzed the combined cell population, focusing on genes associated with disease severity. Distinct cell populations were detected in both BAL
Document: Hyperactive and damaging inflammation is a hallmark of severe rather than mild COVID-19 syndrome. To uncover key inflammatory differentiators between severe and mild COVID-19 disease, we applied an unbiased single-cell transcriptomic analysis. We integrated a bronchoalveolar lavage (BAL) dataset with a peripheral blood mononuclear cell dataset (PBMC) and analyzed the combined cell population, focusing on genes associated with disease severity. Distinct cell populations were detected in both BAL and PBMC where the immunomodulatory long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 were highly differentially expressed between mild and severe patients. The detection of other severity associated genes involved in cellular stress response and apoptosis regulation suggests that the pro-inflammatory functions of these lncRNAs may foster cell stress and damage. The lncRNAs NEAT1 and MALAT1 are potential components of immune dysregulation in COVID-19 that may provide targets for severity related diagnostic measures or therapy.
Search related documents:
Co phrase search for related documents- abundant cell type and acute respiratory distress syndrome: 1, 2
- accession number and acute respiratory: 1, 2, 3, 4, 5
- activity change and acute respiratory: 1, 2, 3, 4, 5, 6, 7
- acute respiratory and adaptive immune: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory and additional cluster: 1, 2, 3, 4
- acute respiratory and additional evidence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory and additional marker: 1, 2
- acute respiratory and additional study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory and lncrna neat1: 1
- acute respiratory and lncrnas neat1: 1
- acute respiratory and local infection site: 1
- acute respiratory distress syndrome and adaptive immune: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory distress syndrome and additional evidence: 1, 2, 3, 4, 5, 6, 7
- acute respiratory distress syndrome and additional study: 1, 2, 3, 4, 5, 6, 7
- adaptive immune and additional evidence: 1
- adaptive immune and local infection site: 1
Co phrase search for related documents, hyperlinks ordered by date