Author: Wang, Yueying; Wang, Zhaojia; Tse, Gary; Zhang, Lin; Wan, Elaine Y.; Guo, Yutao; Lip, Gregory Y. H.; Li, Guangping; Lu, Zhibing; Liu, Tong
Title: Cardiac arrhythmias in patients with COVIDâ€19 Cord-id: s8bm40vy Document date: 2020_7_26
ID: s8bm40vy
Snippet: The emergence of coronavirus disease 2019 (COVIDâ€19), caused by the severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) has become a major global public health concern. Although SARSâ€CoVâ€2 causes primarily respiratory problems, concurrent cardiac injury cannot be ignored since it may be an independent predictor for adverse outcomes. Cardiac arrhythmias are often observed in patients with COVIDâ€19, especially in severe cases, and more likely contribute to the high risk of adv
Document: The emergence of coronavirus disease 2019 (COVIDâ€19), caused by the severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) has become a major global public health concern. Although SARSâ€CoVâ€2 causes primarily respiratory problems, concurrent cardiac injury cannot be ignored since it may be an independent predictor for adverse outcomes. Cardiac arrhythmias are often observed in patients with COVIDâ€19, especially in severe cases, and more likely contribute to the high risk of adverse outcomes. Arrhythmias should be regarded as one of the main complications of COVIDâ€19. Mechanistically, a number of ion channels can be adversely affected in COVIDâ€19, leading to alterations in cardiac conduction and/or repolarization properties, as well as calcium handling, which can predispose to cardiac arrhythmogenesis. In addition, several antimicrobials that are currently used as potential therapeutic agents for COVIDâ€19, such as chloroquine, hydroxychloroquine and azithromycin, have uncertain benefit, and yet may induce electrocardiographic QT prolongation with potential ventricular proâ€arrhythmic effects. Continuous electrocardiogram monitoring, accurate and prompt recognition of arrhythmias are important. The present review focuses on cardiac arrhythmias in patients with COVIDâ€19, its underlying mechanisms, and proposed preventive and therapeutic strategies.
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