Author: S. Willis; J. Masel
Title: Gene birth contributes to structural disorder encoded by overlapping genes Document date: 2017_12_6
ID: 9w2wjiik_47
Snippet: These non-ORF frameshifted control sequences do not take into account the fact that ORFs vary in their propensity to appear and disappear, and that this can shape the material available for de novo gene birth, including ISD values [33] . However, we did not observe this affecting ISD in our data set. In a linear model comparing ORF vs non-ORF non-overlapping control sequences, and one comparing ORF vs. non-ORF pre-overlapping controls sequences, .....
Document: These non-ORF frameshifted control sequences do not take into account the fact that ORFs vary in their propensity to appear and disappear, and that this can shape the material available for de novo gene birth, including ISD values [33] . However, we did not observe this affecting ISD in our data set. In a linear model comparing ORF vs non-ORF non-overlapping control sequences, and one comparing ORF vs. non-ORF pre-overlapping controls sequences, there was no significant difference between the two controls (p = 0.7 in both cases, with frame included as a fixed effect, and gene as a random effect). This justifies a focus on the larger non-ORF control dataset, as well as excluding this non-adaptive force as a driver of the birth facilitation hypothesis.
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