Author: Velmurugan, Ganesan; Vasudevan, Dinakaran
Title: Metagenomic analysis of RNA-sequencing data reveals SARS-CoV-2 mediated progressive dysbiosis of upper respiratory tract microbiota Cord-id: kvysl8xh Document date: 2021_2_27
ID: kvysl8xh
Snippet: COVID-19, an infectious disease caused by a novel coronavirus (SARS-CoV-2) has emerged as global pandemic. Here, we are describing the changes in microbiota of upper respiratory tract by analyzing the publically available RNA-sequencing data of SARS-CoV-2 infected ferrets. The bacterial dysbiosis due to SARS-CoV-2 is largely inversely proportional to the dysbiosis caused by influenza-A virus. The bacterial taxa, which are defined as healthy ecostate are significantly reduced during SARS-CoV-2 in
Document: COVID-19, an infectious disease caused by a novel coronavirus (SARS-CoV-2) has emerged as global pandemic. Here, we are describing the changes in microbiota of upper respiratory tract by analyzing the publically available RNA-sequencing data of SARS-CoV-2 infected ferrets. The bacterial dysbiosis due to SARS-CoV-2 is largely inversely proportional to the dysbiosis caused by influenza-A virus. The bacterial taxa, which are defined as healthy ecostate are significantly reduced during SARS-CoV-2 infection. Altogether, this preliminary study provides a new insight on the possible role of bacterial communities of upper respiratory tract in determining the immunity, susceptibility, and mortality for COVID-19.
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