Author: Weiskopf, Daniela; Schmitz, Katharina S.; Raadsen, Matthijs P.; Grifoni, Alba; Okba, Nisreen M.A.; Endeman, Henrik; van den Akker, Johannes P.C.; Molenkamp, Richard; Koopmans, Marion P.G.; van Gorp, Eric C.M.; Haagmans, Bart L.; de Swart, Rik L.; Sette, Alessandro; de Vries, Rory Dylan
Title: Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome Cord-id: 97gme3pl Document date: 2020_4_18
ID: 97gme3pl
Snippet: COVID-19 is associated with lymphopenia and cytokine storm, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity.
Document: COVID-19 is associated with lymphopenia and cytokine storm, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity.
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