A Multiscale and Comparative Model for Receptor Binding of 2019 Novel Coronavirus and the Implication of its Life Cycle in Host Cells

Zhaoqian Su; Yinghao Wu

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint Figure 4 : Given predefined weights for all the rate parameters and the initial values for 1 each variable in the model, the dynamics of the system is evolved as a function of time by 2 solving the mathematical model numerically with a stochastic simulation algorithm. The 3 figure suggests that the dynamics of the system can be divided into three stages (a). We 4 further applied the model to two comparative systems. A relatively fast viral binding rate 5 k b was adopted in the first system to represent the binding process of SARS, while a 6 relatively slow rate was adopted in the second to represent the binding process of 2019-7 nCoV. As shown in (b), we found that the first stage in the simulation of 2019-nCoV (red 8 curve) is longer than the simulation of SARS (black curve), while the level of free virus 9 at the end of the first period in 2019-nCoV is relatively higher than the corresponding 10 level of free virus in SARS. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10. 1101