140 SARS-CoV 2 antibody response among women infected during pregnancy at Mount sinai hospital

Buckley, Ayisha B.; Mills, Ariana; Paul, Keisha; Raymond, Samantha; Rosenberg, Henri M.; DeBolt, Chelsea; Cohen, Natalie; Wajnberg, Ania; Vieira, Luciana; Stone, Joanne; Bianco, Angela

Objective: We examined the antibody response of pregnant women who delivered at Mount Sinai Hospital with a SARS-CoV 2 infection between the study interval of March 15, 2020 through April 30, 2020. Study Design: This was a prospective observational study examining the immune response of pregnant women who delivered at Mount Sinai Hospital with a PCR confirmed SARS-CoV 2 infection. Women with a SARS-CoV 2 infection were contacted via phone and scheduled for a phlebotomy visit to assess their antibody titer levels to COVID 19. The COVID-19 ELISA IgG Antibody Test was used to evaluate the patients’ antibody titers. Results: 122 patients were identified as being diagnosed and delivered with SARS-CoV 2 in the pre-specified time frame. Of those patients, 25 women agreed to participate and were included in this study. 64.00% were Caucasian with an average age of 35 years. Demographic variables are illustrated in Table 1. The majority of women were asymptomatic for COVID-19 at the time of admission (80.00 %) and the average gestational age of delivery and diagnosis of COVID-19 was 39 weeks gestation (Table 1). The later the gestational age at the time of diagnosis, the lower the antibody titer response (Table 2). When examining interval from diagnosis to antibody titer level, patients with the highest titers (2880) tended to have a shorter interval between their COVID-19 diagnosis and the time at which the titer level was drawn (73 vs 87 vs 77 days for patients with titers of 1:2880, 960 and 320 respectively). In addition, patients with symptoms on admission were slightly more likely to have a higher antibody titer level (80.00% of symptomatic patients had a reported antibody level of 960 or 2880). Conclusion: The antibody response among women infected with COVID-19 during pregnancy, appears to be greater when the patients are diagnosed at an earlier gestational age. Antibody titers were assessed greater than 4 weeks from the time of initial diagnosis, however beyond this time period the shorter the interval between diagnosis and assessment of antibody titer level, the more robust the apparent immune response. [Formula presented] [Formula presented]