Author: Fani, Mona; Khodadad, Nastaran; Ebrahimi, Saeedeh; Nahidsamiei, Rahil; Makvandi, Manoocher; Teimoori, Ali; Langari, Hadis
Title: Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay Cord-id: tmkfju93 Document date: 2019_4_26
ID: tmkfju93
Snippet: This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO(4)) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO(4) strongly inhibited the replication of virus progeny (MOI 0.001) at least 68-fold less. On the other hand, the IC50 demonstrated that the highest activity of ZnSO(4) was at the 0.23 mM concentration.
Document: This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO(4)) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO(4) strongly inhibited the replication of virus progeny (MOI 0.001) at least 68-fold less. On the other hand, the IC50 demonstrated that the highest activity of ZnSO(4) was at the 0.23 mM concentration.
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