Author: Scully, Eileen P.; Haverfield, Jenna; Ursin, Rebecca L.; Tannenbaum, Cara; Klein, Sabra L.
Title: Considering how biological sex impacts immune responses and COVID-19 outcomes Cord-id: tv014ubp Document date: 2020_6_11
ID: tv014ubp
Snippet: A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation and tissue repair in the resolution of infection. We discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity
Document: A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation and tissue repair in the resolution of infection. We discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity. We propose that sex differences in immunopathogenesis will inform mechanisms of COVID-19, identify points for therapeutic intervention and improve vaccine design and increase vaccine efficacy.
Search related documents:
Co phrase search for related documents- aberrant activation and acute ards respiratory distress syndrome: 1
- aberrant activation and acute infection: 1, 2, 3
- aberrant activation and adaptive immune response: 1, 2, 3, 4
- aberrant activation and adaptive immunity: 1, 2, 3, 4
- aberrant activation and adaptive innate: 1, 2, 3, 4, 5, 6
- aberrant activation and adaptive innate immune response: 1, 2
- aberrant activation and lung injury: 1, 2, 3, 4, 5, 6, 7
- aberrant activation and lung tissue: 1, 2, 3, 4
- aberrant activation and macrophage activation: 1, 2
- activation interferon and acute ards respiratory distress syndrome: 1, 2
- activation interferon and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- activation interferon and adaptive immune response: 1, 2, 3, 4, 5, 6
- activation interferon and adaptive immunity: 1, 2, 3, 4
- activation interferon and adaptive innate: 1, 2, 3, 4, 5, 6, 7
- activation interferon and adaptive innate immune response: 1, 2
- activation interferon and lung injury: 1, 2, 3, 4, 5, 6, 7, 8
- activation interferon and lung tissue: 1, 2, 3, 4, 5, 6, 7
- activation interferon and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9
- acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Co phrase search for related documents, hyperlinks ordered by date