Author: Maja von Cube; Marlon Grodd; Martin Wolkewitz; Derek Hazard; Jerome Lambert
Title: Harmonizing heterogeneous endpoints in COVID-19 trials without loss of information - an essential step to facilitate decision making Document date: 2020_4_3
ID: bsddxgx2_21
Snippet: Besides these potentials, both of the proposed multistate models have the limitation that they do not account for patient triage possibly necessitated by ICU congestion (19). Additional research is needed to avoid selection bias arising from this special clinical situation. Finally, our proposal should be understood as a complement for the primary analysis. Rather than suggesting COS for COVID-19 trials, we provide a way for simultaneous evaluati.....
Document: Besides these potentials, both of the proposed multistate models have the limitation that they do not account for patient triage possibly necessitated by ICU congestion (19). Additional research is needed to avoid selection bias arising from this special clinical situation. Finally, our proposal should be understood as a complement for the primary analysis. Rather than suggesting COS for COVID-19 trials, we provide a way for simultaneous evaluation of multiple endpoints within COS using information all of the available data.
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